Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation

Boccella N, Paolillo R, Coretti L, D’Apice S, Lama A, Giugliano G, Schiattarella GG, Cuomo M, d’Aquino I, Cavaliere G, Paciello O, Mollica MP, Mattace Raso G, Esposito G, Lembo F, Perrino C.
Sci Rep. 2021 Apr 1;11(1):7404. doi: 10.1038/s41598-021-86651-y. PMID: 33795775 Free PMC article.
In this study we systematically analysed gut microbiota composition, intestinal barrier integrity, intestinal and serum cytokines and serum endotoxin levels in C57BL/6 mice undergoing pressure overload by transverse aortic constriction (TAC) for …