Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice

He B, Jiang J, Shi Z, Wu L, Yan J, Chen Z, Luo M, Cui D, Xu S, Yan M, Zhang S, Chen Z.
Biomed Pharmacother. 2021 Jan 2;135:111183. doi: 10.1016/j.biopha.2020.111183. Online ahead of print. PMID: 33401222
Here, we discuss on the mechanism of PTFC in treating NASH with focus on the regulation of the gut microbiota and bile acid metabolism. METHODS: C57BL/6 J mice were randomly divided into three groups: normal diet group (Normal), high-fat diet group (HFD) and high-fat + PTF …