Post-translational suppression of the high affinity IgE receptor expression on mast cells by an intestinal bacterium

Fukatsu S, Horinouchi H, Nagata S, Kamei R, Tanaka D, Hong W, Kazami Y, Fujimori M, Itoh K, Momose Y, Kasakura K, Hosono A, Kaminogawa S, Hanazawa S, Nakanishi Y, Takahashi K.
Immunobiology. 2021 Jan 23;226(2):152056. doi: 10.1016/j.imbio.2021.152056. Online ahead of print. PMID: 33535092
The suppressive effect required sustained exposure to this bacterium, with a corresponding reduction in Erk activation. Inhibition of Erk decreased cell surface distribution of FcepsilonRI in BMMCs, at least in part, through facilitated endocytosis of FcepsilonRI. These re …