NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation

van der Post S, Birchenough GMH, Held JM.
Cell Rep. 2021 Apr 6;35(1):108949. doi: 10.1016/j.celrep.2021.108949. PMID: 33826887
However, the molecular link connecting the diverse inputs that maintain CSC homeostasis remains largely unknown. We report that CSC proliferation is mediated by redoxdependent activation of epidermal growth factor receptor (EGFR) signaling via NADPH oxidase …