Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation

Nayak RR, Alexander M, Deshpande I, Stapleton-Gray K, Rimal B, Patterson AD, Ubeda C, Scher JU, Turnbaugh PJ.
Cell Host Microbe. 2021 Jan 7:S1931-3128(20)30670-3. doi: 10.1016/j.chom.2020.12.008. Online ahead of print. PMID: 33440172
Methotrexate (MTX), a first-line rheumatoid arthritis (RA) treatment, inhibits mammalian dihydrofolate reductase (DHFR), but whether it directly impacts gut bacteria is unclear. We show that MTX broadly alters the human gut microbiota. …Thus, conservation in cellu …