Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease

Shapiro JM, de Zoete MR, Palm NW, Laenen Y, Bright R, Mallette M, Bu K, Bielecka AA, Xu F, Hurtado-Lorenzo A, Shah SA, Cho JH, LeLeiko NS, Sands BE, Flavell RA, Clemente JC.
Cell Host Microbe. 2020 Dec 31:S1931-3128(20)30665-X. doi: 10.1016/j.chom.2020.12.003. Online ahead of print. PMID: 33385335
Patients treated with anti-TNF-alpha therapies exhibited dramatically altered microbiota-specific IgA responses compared with controls. Furthermore, increased IgA coating of Oscillospira was associated with a delay in time to surgery. These results demonstrate that investi …