Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8 + T cell immunity

He Y, Fu L, Li Y, Wang W, Gong M, Zhang J, Dong X, Huang J, Wang Q, Mackay CR, Fu YX, Chen Y, Guo X.
Cell Metab. 2021 Mar 18:S1550-4131(21)00109-1. doi: 10.1016/j.cmet.2021.03.002. Online ahead of print. PMID: 33761313
However, the underlying mechanism is not clear yet. Here, we found that gut microbial metabolites, especially butyrate, could promote the efficacy of oxaliplatin by modulating CD8(+) T cell function in the tumor microenvironment. …In humans, the oxaliplatin …