Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8 + T cell immunity
Cell Metab. 2021 Mar 18:S1550-4131(21)00109-1. doi: 10.1016/j.cmet.2021.03.002. Online ahead of print. PMID: 33761313
However, the underlying mechanism is not clear yet. Here, we found that gut microbial metabolites, especially butyrate, could promote the efficacy of oxaliplatin by modulating CD8(+) T cell function in the tumor microenvironment. …In humans, the oxaliplatin …