MicrobiotaMi 072

A deep relationship between the gut microbiota and immune cells dynamics in humans

MicrobiotaMi Comment 06_21 
by Federica Spaggiari

The gut microbiota has a fundamental role in modulating the activity of the immune system, its efficiency and its composition. Indeed, multiple studies highlighted the deep connection between gut microbiome composition and immunotherapies diverse outcomes.

Dietary changes induce alterations in adult neurogenesis via mitochondrial pathways

MicrobiotaMi Comment 05_21
by Stefania Blasa

The importance of diet in brain health and neurological function has gained increasing interest in the last years. Dietary factors are well known to influence the composition of gut microbiota, which regulates several brain functions through the gut microbiota-brain axis and whose imbalance lead to …

MicrobiotaMi-068

Microbiota transplantation may not be as advantageous as dietary interventions in the treatment of NAFLD

MicrobiotaMi Comment 04_21
by Martina Morandi

Nonalcoholic fatty liver disease (NAFLD) refers to a common disorder characterised by an excessive accumulation of fat in the liver that begins from a mild steatosis to nonalcoholic steatohepatitis (NASH), that left untreated can lead to fibrosis, cirrhosis and hepatocellular carcinoma.

The role of gut microbiome in mutant p53 oncogenic activity modulation

MicrobiotaMi Comment 03_21
by Federica Spaggiari

The role of p53 in the maintenance of cell homeostasis and in the control of its proliferation is well-known. The longest recognized activity of the wild type form of p53 is the tumour-suppressive one. Acting both as a transcription factor and as a direct effector, p53 promotes the arrest of cell-cycle, apoptosis or senescence when severe …

The circadian rhythm and the microbiota-gut-brain axis: a recurrent appointment with the neighbours

MicrobiotaMi Comment 02_21
by  Giulia Colombo

Teichman et al.’s recent review deals with the interactions between the microbiota-gut-brain axis and circadian rhythmicity, a topic that reminds us how reductive it is to think about ourselves as lonely bodies: we are more similar to small-scale ecosystems, instead, for our microbiota partners…

The impact of gut microbiota-brain axis in neurological disorders

MicrobiotaMi Comment 01_21 
by  Stefania Blasa

All animals have developed a strict association with microbial communities during the evolution. This collection of microorganisms, termed the microbiota, is particularly abundant in the gastrointestinal tract and can regulate the function of our metabolism, immune system and even the development of the nervous system. Gut microbiota can influence the brain …

MicrobiotaMi 018

The role of gut microbiota and metabolites in protecting against radiation injury

MicrobiotaMi Comment 03_20
by Roberto Ferrarese

One of the most longstanding and unresolved problems in radiotherapy is radiation injury: after partial or total body exposure to ionizing radiation, an acute radiation syndrome or sickness (ARS) may occur, leading to poor hematopoietic recovery and injury to gastrointestinal tract. Although some previous studies showed the …

MicrobiotaMi 019

Antiviral potential of the gut microbiota

MicrobiotaMi Comment 02_20
by Benedetta Sposito

Type I Interferons (IFN-I) represent one of the first lines of defense against viral infections. They are rapidly upregulated by almost every cell in the body upon stimulation of different pattern recognition receptors. However, low levels of IFN-I are constitutively expressed and play homeostatic functions. The cellular sources and the stimuli that regulate IFN-I induction in the absence of infection are still under study.

MicrobiotaMi 023

The relationship between microbiota and human local adaptation

MicrobiotaMi Comment 01_20
by Marco Tonelli

It is well known that human beings had to genetically adapt themselves to the different local conditions across the entire world: in particular they had to adapt to different climates, diets and pathogens that can be encountered during lifetime. As an example, it is very clear the important role of hypoxia-inducible facto 2-alpha (encoded by EPAS1) for people who live in high altitudes, or even the beta-globin gene haplotypes …