MicrobiotaMi 072

A deep relationship between the gut microbiota and immune cells dynamics in humans

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MicrobiotaMi Comment 06_21 
by Federica Spaggiari

The gut microbiota has a fundamental role in modulating the activity of the immune system, its efficiency and its composition. Indeed, multiple studies highlighted the deep connection between gut microbiome composition and immunotherapies diverse outcomes.

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The role of gut microbiome in mutant p53 oncogenic activity modulation

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MicrobiotaMi Comment 03_21
by Federica Spaggiari

The role of p53 in the maintenance of cell homeostasis and in the control of its proliferation is well-known. The longest recognized activity of the wild type form of p53 is the tumour-suppressive one. Acting both as a transcription factor and as a direct effector, p53 promotes the arrest of cell-cycle, apoptosis or senescence when severe …

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