Federica Spaggiari

Bacteria-derived peptides are presented by HLA molecules in melanoma

Bacteria-derived peptides are presented by HLA molecules in melanoma

MicrobiotaMi Comment 28_21
by Federica Spaggiari

A large amount of bacteria colonize healthy mucosal tissue of the human body from early life and create a symbiotic relationship with the host organism. The commensal flora composition varies between individuals and life stages. More recently, tumour-resident bacteria has captured the attention of the scientific community. Indeed, multiple studies are focused on understanding the role of specific microbial populations within …

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Clostridioides difficile behaviour in the inflamed gut: a transcriptional and microbial composition alteration

Clostridioides difficile behaviour in the inflamed gut: a transcriptional and microbial composition alteration

MicrobiotaMi Comment 27_21
by Federica Spaggiari

Clostridioides difficile is a Gram positive, spore-forming and ubiquitous anaerobe that can be easily found in the soil. C. difficile is a member of the normal human gut flora even if its growth and activity are suppressed by more dominant anaerobes in healthy conditions. The rate of gut colonization varies among age groups. In particular, it is abundant during infancy,….

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Does the gut microbiota influence the peripheral immune response in NAFLD-related hepatocellular carcinoma?

Does the gut microbiota influence the peripheral immune response in NAFLD-related hepatocellular carcinoma?

MicrobiotaMi Comment 18_21
by Federica Spaggiari

Dysbiosis is widely known as one of the causes and drivers of the rise and development of several and diverse diseases. Moreover, microbiota is able to modulate the organism’s immune response, mainly through its metabolic activity. Thus, the patient’s outcome is closely dependent on the ability of the microbiota to suppress or boost the immune system’s activity.

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The role of gut microbiome in mutant p53 oncogenic activity modulation

The role of gut microbiome in mutant p53 oncogenic activity modulation

MicrobiotaMi Comment 03_21
by Federica Spaggiari

The role of p53 in the maintenance of cell homeostasis and in the control of its proliferation is well-known. The longest recognized activity of the wild type form of p53 is the tumour-suppressive one. Acting both as a transcription factor and as a direct effector, p53 promotes the arrest of cell-cycle, apoptosis or senescence when severe …

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