DYSBIOTIC GUT MICROBIOTA AND IMPAIRED IMMUNE RESPONSE PROMOTE HEPATIC INFLAMMATION PROGRESSION AND HEPATOCELLULAR CARCINOMA DEVELOPMENT Hepatocellular carcinoma (HCC) complexity and aggressiveness pose a great challenge for the development of effective preventive and...
MicrobiotaMi Comment 28_21
by Federica Spaggiari
A large amount of bacteria colonize healthy mucosal tissue of the human body from early life and create a symbiotic relationship with the host organism. The commensal flora composition varies between individuals and life stages. More recently, tumour-resident bacteria has captured the attention of the scientific community. Indeed, multiple studies are focused on understanding the role of specific microbial populations within …
MicrobiotaMi Comment 27_21
by Federica Spaggiari
Clostridioides difficile is a Gram positive, spore-forming and ubiquitous anaerobe that can be easily found in the soil. C. difficile is a member of the normal human gut flora even if its growth and activity are suppressed by more dominant anaerobes in healthy conditions. The rate of gut colonization varies among age groups. In particular, it is abundant during infancy,….
MicrobiotaMi Comment 18_21
by Federica Spaggiari
Dysbiosis is widely known as one of the causes and drivers of the rise and development of several and diverse diseases. Moreover, microbiota is able to modulate the organism’s immune response, mainly through its metabolic activity. Thus, the patient’s outcome is closely dependent on the ability of the microbiota to suppress or boost the immune system’s activity.
MicrobiotaMi Comment 10_21
by Federica Spaggiari
Fusobacterium nucleatum is a commensal bacterium of the oral cavity and other mucosal sites. It is found in the same districts in pathogenic conditions too so it can be ascribed to the opportunistic pathogens category as well. Normally, F. nucleatum in the oral cavity contributes to…
MicrobiotaMi Comment 06_21
by Federica Spaggiari
The gut microbiota has a fundamental role in modulating the activity of the immune system, its efficiency and its composition. Indeed, multiple studies highlighted the deep connection between gut microbiome composition and immunotherapies diverse outcomes.
MicrobiotaMi Comment 03_21
by Federica Spaggiari
The role of p53 in the maintenance of cell homeostasis and in the control of its proliferation is well-known. The longest recognized activity of the wild type form of p53 is the tumour-suppressive one. Acting both as a transcription factor and as a direct effector, p53 promotes the arrest of cell-cycle, apoptosis or senescence when severe …