Bacteria-derived peptides are presented by HLA molecules in melanoma

MicrobiotaMi Comment 28_21
by Federica Spaggiari

A large amount of bacteria colonize healthy mucosal tissue of the human body from early life and create a symbiotic relationship with the host organism. The commensal flora composition varies between individuals and life stages. More recently, tumour-resident bacteria has captured the attention of the scientific community. Indeed, multiple studies are focused on understanding the role of specific microbial populations within …

Clostridioides difficile behaviour in the inflamed gut: a transcriptional and microbial composition alteration

MicrobiotaMi Comment 27_21
by Federica Spaggiari

Clostridioides difficile is a Gram positive, spore-forming and ubiquitous anaerobe that can be easily found in the soil. C. difficile is a member of the normal human gut flora even if its growth and activity are suppressed by more dominant anaerobes in healthy conditions. The rate of gut colonization varies among age groups. In particular, it is abundant during infancy,….

Does the gut microbiota influence the peripheral immune response in NAFLD-related hepatocellular carcinoma?

MicrobiotaMi Comment 18_21
by Federica Spaggiari

Dysbiosis is widely known as one of the causes and drivers of the rise and development of several and diverse diseases. Moreover, microbiota is able to modulate the organism’s immune response, mainly through its metabolic activity. Thus, the patient’s outcome is closely dependent on the ability of the microbiota to suppress or boost the immune system’s activity.

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Effects of colonization by Fusobacterium nucleatum on breast cancer growth and progression

MicrobiotaMi Comment 10_21 
by Federica Spaggiari

Fusobacterium nucleatum is a commensal bacterium of the oral cavity and other mucosal sites. It is found in the same districts in pathogenic conditions too so it can be ascribed to the opportunistic pathogens category as well. Normally, F. nucleatum in the oral cavity contributes to…

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A deep relationship between the gut microbiota and immune cells dynamics in humans

MicrobiotaMi Comment 06_21 
by Federica Spaggiari

The gut microbiota has a fundamental role in modulating the activity of the immune system, its efficiency and its composition. Indeed, multiple studies highlighted the deep connection between gut microbiome composition and immunotherapies diverse outcomes.

The role of gut microbiome in mutant p53 oncogenic activity modulation

MicrobiotaMi Comment 03_21
by Federica Spaggiari

The role of p53 in the maintenance of cell homeostasis and in the control of its proliferation is well-known. The longest recognized activity of the wild type form of p53 is the tumour-suppressive one. Acting both as a transcription factor and as a direct effector, p53 promotes the arrest of cell-cycle, apoptosis or senescence when severe …