Gut Microbiota-Neuron-Treg Triangle

MicrobiotaMi Comment 25_21
by Benedetta Sposito

It is well known that the microbiota influences the development and skewing of the intestinal immune system. Among the multiplicity of innate and adaptive immune cells that colonize the intestine, regulatory T cells (Tregs) are critical for maintaining tissue homeostasis and tolerance to commensal bacteria. Previous reports have described the ability of specific commensals to induce differentiation of RORγ+ Tregs in the mouse colon. Interestingly, these microbial …

Ecology of the multi-kingdom human gut microbiota assembly: insights from preterm infants

MicrobiotaMi Comment 24_21
by Giulia Colombo

The new-born human gut is like a desert island for the microbiota: in fact, it evolves predictably with pioneer species colonizing the gut after birth, followed by an ordered succession of microorganisms. This colonizing process can be studied in a privileged manner in preterm infants, as well as the potentially shaping influences of the environment, the host and interactions …

Lung cancer and oral microbiota: possible connections in never-smokers

MicrobiotaMi Comment 23_21
by Marco Tonelli

Lung cancer is the first cause of death among cancer-related deaths. The majority of cases is related to tobacco smoking, nevertheless, 25% of lung cancer cases occur in non-smokers. As we already know, there are lots of other risk factors, such as household and outdoor air pollution, secondhand tobacco smoke, radon exposure and so on. The study by Hosgood et al., published on Thorax, aims at finding an association between …

Investigating the potential effects of inulin on gut microbiota of schizophrenia-affected mice

MicrobiotaMi Comment 22_21
by Stefania Blasa

Schizophrenia (SCZ) is a heterogeneous neurodevelopmental disorder, which causes psychosis in 1% of worldwide patients, disability and socioeconomic burdens on public health. Its etiology is multifactorial and includes genetic causes and environmental risk factors.
The gut-brain axis influences neurotransmission, neurogenesis …

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The importance of fiber in the maintenance of human gut microbiota health

MicrobiotaMi Comment 21_21
by Martina Morandi

Food is one of the most singularly important factors in overall health and a healthy diet is the cornerstone for a healthier life. Generally speaking, a diverse gut microbiota is considered to be more beneficial for the host, this is because the more species of bacteria you have, the greater number of benefits they may be able to contribute to. A diet rich of different food types can lead to …

Association between respiratory and gut microbiomes in SARS-CoV-2 infected patients

MicrobiotaMi Comment 20_21
by Roberto Ferrarese

As we sadly know, SARS-CoV-2 virus has led to a devastating global pandemic during the past year. It has been already observed that in COVID-19 patients was present a dysbiosis that led to an enrichment of opportunistic pathogens and a depletion of beneficial bacteria. However, alterations in the respiratory microbiome of COVID-19 patients have not been


Exercise produces beneficial effects on hypertension via gut-brain axis improvement

MicrobiotaMi Comment 19_21
by Stefania Blasa

Hypertension (HTN) is a serious condition in which blood pressure in the arteries is constantly elevated due to several causes, such as smoking, elevate body weight, alcohol or genetic factors and if not treated it could lead to stroke, heart failure, vision loss, chronic kidney disease and dementia. Several evidences support the presence of a dysfunctional gut-brain axis in

Does the gut microbiota influence the peripheral immune response in NAFLD-related hepatocellular carcinoma?

MicrobiotaMi Comment 18_21
by Federica Spaggiari

Dysbiosis is widely known as one of the causes and drivers of the rise and development of several and diverse diseases. Moreover, microbiota is able to modulate the organism’s immune response, mainly through its metabolic activity. Thus, the patient’s outcome is closely dependent on the ability of the microbiota to suppress or boost the immune system’s activity.

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Kin to win: kin selection drives cooperation in the human gut microbiota

MicrobiotaMi Comment 17_21
by Giulia Colombo

The management of complex microbial communities is a very promising tool in many fields, from microbiome manipulation to sustainable food production and climate regulation. To successfully engineer …

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Post-traumatic stress disorder model shows changes in neurotransmitter production and gut microbiota composition

MicrobiotaMi Comment 16_21
by Stefania Blasa

The gut microbiota has recently attracted large research attention due to its ability to regulate the brain-gut axis. The central nervous system regulates the