MicrobiotaMi Comment 02_20
by Benedetta Sposito
Type I Interferons (IFN-I) represent one of the first lines of defense against viral infections. They are rapidly upregulated by almost every cell in the body upon stimulation of different pattern recognition receptors. However, low levels of IFN-I are constitutively expressed and play homeostatic functions. The cellular sources and the stimuli that regulate IFN-I induction in the absence of infection are still under study.