Calorie restriction prevents age-related changes in the intestinal microbiota

Kurup K, Matyi S, Giles CB, Wren JD, Jones K, Ericsson A, Raftery D, Wang L, Promislow D, Richardson A, Unnikrishnan A.
Aging (Albany NY). 2021 Mar 10;13(5):6298-6329. doi: 10.18632/aging.202753. Epub 2021 Mar 10. PMID: 33744869
The effect of calorie restriction (CR) on the microbiome, fecal metabolome, and colon transcriptome of adult and old male mice was compared. Life-long CR increased microbial diversity and the Bacteroidetes/Firmicutes ratio and prevented the agerela