A gut matter: the parallel aging of the microbiota and the brain

MicrobiotaMi Comment 30_21
by Giulia Colombo

Age-related cognitive decline is associated with chronic low grade neuroinflammation that may result from a complex interplay among many factors, such as bidirectional communication between the central nervous system (CNS) and gut microbiota. This usually occurs through the immune, the neuroendocrine and the vagal pathways. Wu et al. compared 2-month-old (young) and 15-month-old (aged) mice to explore …


Gut microbiota a key player in healthy aging

MicrobiotaMi Comment 29_21
by Martina Morandi

Extrinsic factors, such as lifestyle, diet, medication, physical activity, are essential in the control of human healthy aging and they can have a significant impact on gut microbiota. The latter is not a static entity, but it changes throughout the lifespan becoming increasingly unique to individuals with age. Several studies have investigating the gut microbiota of centenarians and supercentenarians showing that even if …

Bacteria-derived peptides are presented by HLA molecules in melanoma

MicrobiotaMi Comment 28_21
by Federica Spaggiari

A large amount of bacteria colonize healthy mucosal tissue of the human body from early life and create a symbiotic relationship with the host organism. The commensal flora composition varies between individuals and life stages. More recently, tumour-resident bacteria has captured the attention of the scientific community. Indeed, multiple studies are focused on understanding the role of specific microbial populations within …

Clostridioides difficile behaviour in the inflamed gut: a transcriptional and microbial composition alteration

MicrobiotaMi Comment 27_21
by Federica Spaggiari

Clostridioides difficile is a Gram positive, spore-forming and ubiquitous anaerobe that can be easily found in the soil. C. difficile is a member of the normal human gut flora even if its growth and activity are suppressed by more dominant anaerobes in healthy conditions. The rate of gut colonization varies among age groups. In particular, it is abundant during infancy,….


The role of neonatal microbiota in myelination and signaling of the gut-brain axis

MicrobiotaMi Comment 26_21
by Stefania Blasa

The gut microbiota has a crucial role in the development of brain, gut and immune system. Alterations in its components could induce several diseases, such as gastrointestinal disease, irritable bowel syndrome and psychological disorders such as depression and autism. The bidirectional communication between gut and brain through the microbiota-gut-brain …