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Microbiota transplantation may not be as advantageous as dietary interventions in the treatment of NAFLD

MicrobiotaMi Comment 04_21
by Martina Morandi

Nonalcoholic fatty liver disease (NAFLD) refers to a common disorder characterised by an excessive accumulation of fat in the liver that begins from a mild steatosis to nonalcoholic steatohepatitis (NASH), that left untreated can lead to fibrosis, cirrhosis and hepatocellular carcinoma.

The role of gut microbiome in mutant p53 oncogenic activity modulation

MicrobiotaMi Comment 03_21
by Federica Spaggiari

The role of p53 in the maintenance of cell homeostasis and in the control of its proliferation is well-known. The longest recognized activity of the wild type form of p53 is the tumour-suppressive one. Acting both as a transcription factor and as a direct effector, p53 promotes the arrest of cell-cycle, apoptosis or senescence when severe …