Entries by MicrobiotaMi

Bacteria-derived peptides are presented by HLA molecules in melanoma

MicrobiotaMi Comment 28_21
by Federica Spaggiari

A large amount of bacteria colonize healthy mucosal tissue of the human body from early life and create a symbiotic relationship with the host organism. The commensal flora composition varies between individuals and life stages. More recently, tumour-resident bacteria has captured the attention of the scientific community. Indeed, multiple studies are focused on understanding the role of specific microbial populations within …

Clostridioides difficile behaviour in the inflamed gut: a transcriptional and microbial composition alteration

MicrobiotaMi Comment 27_21
by Federica Spaggiari

Clostridioides difficile is a Gram positive, spore-forming and ubiquitous anaerobe that can be easily found in the soil. C. difficile is a member of the normal human gut flora even if its growth and activity are suppressed by more dominant anaerobes in healthy conditions. The rate of gut colonization varies among age groups. In particular, it is abundant during infancy,….

The role of neonatal microbiota in myelination and signaling of the gut-brain axis

MicrobiotaMi Comment 26_21
by Stefania Blasa

The gut microbiota has a crucial role in the development of brain, gut and immune system. Alterations in its components could induce several diseases, such as gastrointestinal disease, irritable bowel syndrome and psychological disorders such as depression and autism. The bidirectional communication between gut and brain through the microbiota-gut-brain …

Gut Microbiota-Neuron-Treg Triangle

MicrobiotaMi Comment 25_21
by Benedetta Sposito

It is well known that the microbiota influences the development and skewing of the intestinal immune system. Among the multiplicity of innate and adaptive immune cells that colonize the intestine, regulatory T cells (Tregs) are critical for maintaining tissue homeostasis and tolerance to commensal bacteria. Previous reports have described the ability of specific commensals to induce differentiation of RORγ+ Tregs in the mouse colon. Interestingly, these microbial …