The aim of this International meeting is to focus on the molecular mechanisms and interactions in health and disease conditions beyond infection, including sensitization, gut-brain communication, aging, cancer, chronic inflammation and autoimmunity.
Motivation for the selection of this topic is that despite a huge increase in genomic, proteomic and metabolomics data that allowed to relate microbiota composition to health and disease of different organs, the molecular mechanisms by which bacteria, viruses and fungi communicate with the host organism remain largely unknown.
In this context the key role is played by the Pattern Recognition Receptors (PRRs), including Toll-like Receptors (TLRs) but also intracellular NLRs and other receptors.